In the fallout from House of M and following the surprise film-noir hit Madrox, a new mutant team is forged!

X-Factor is an investigative mutant agency that includes Madrox, the Multiple Man; Guido, the Strong Guy; Wolfsbane, the shape-shifter; Siryn, the chorus girl; Rictor, the living earthquake; and Generation X's Monet, the pompous witch. Drawn together in the heart of District X, this rag-tag band of heroes has a lot of answers to find, and fast!